The quinuclidine PHA 568487 is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).

Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway.